Indeed, for Windows users this will definitely require a GUI of some kind, simply because of historical reasons.
Linux users (like myself) should certainly be able to get by without a GUI, but I'm sure one would be appreciated nonetheless.
OSX, it's probably 50/50. As a Mac Book Pro owner, I use Homebrew enough for package management that I could easily do without the GUI. But again, considering the history of graphical applications in OS X and Windows, a GUI would likely be appreciated.
I believe that the Qt QML approach is a strong bet, especially considering that a number of systems have these libraries installed already, versus something like Mono. In addition, Vapoursynth already uses some of the Qt libraries, so there is a nice parallel there.
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