It's worth noting that HEVC can do both transform skip (--tskip) which is lossy encoding but without the initial frequency domain transform for a CU and Lossless CU (--cu-lossless) which is true lossless encoding of a CU. Both can be used on a per CU basis, and both can be used in the same frame.
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Ben Waggoner
Principal Video Specialist, Amazon Prime Video
My Compression Book
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