0. In theory it is possible to build x265 for Windows with clang.
1. From my speed tests, if your CPU doesn't have SSE4, the fastest are GCC 6 builds, otherwise VS 2015 builds.
2. For current CPU (AVX/AVX2) the best are VS 2015 builds. Windows version isn't important if it is Windows 7 64bit or newer 64bit.
3. Yes, there are (but very small). In file source/encoder/sao.cpp some decisions are made according to floating point computations that depends on compiler/optimize options.
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