Not really.. with zones coming (I'm currently testing the most evil scenarios and try to make it crash), the x264 config dialog will look differently, so do the settings. Then as you can see from the development forum, there will be new dialogs in the future, along with a restructured dgindex project creator, a chapter creator, etc. And of course the codec dialog screens can be changed at any time (new features, make things more userfriendly, etc... but this is the same with VfW codecs).
I know why you're asking though and I'd say it's safe to start with the guide now. The big changes have been done. If you use the latest release you should be okay.