I can make a few suggestions, and point a few possibilities. First, I didn't see mention of what OS you are using. I use Win 10 and found some tweaks with Windows Defender. I added the executablles for X265, ffmpeg, AVSpipe... (it's a long name) to the process exclusion list. That has the effect of letting Defender operate as "hands off" when these things are running.
Another thing to try would be adding Prefetch at the end of the chain. That is essential for some filters.
Finally, if you are using X265, you already know that it may not be possible to reach 100% saturation of the CPU, just by the virtue of the way X265 works.
I hope that offers some help.
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