Overdrive80: Thanks again, the OP is updated.
nhope: What exactly are you dragging into Megui to cause the crash? That script doesn't refer to the file you've uploaded. In any case the snippet you sent (it's 4:2:0) works perfectly. I can drag the m2t file directly into the Avisynth Script box and a preview comes up no problem. If I adjust your script to accept it as a source, I can drag that in too. QTGMC happily processes it. This is all on a fully patched dev version of MeGUI.
To get YUY2 out of VDub, you can use ffdshow/HuffyUV and set the Colorspace to YUY2 in ( Compression...>>Configure>>Encoder>>Generic )
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