I'm using ref.4 and b-frames:4 for 1920x1080. The larger b-frame value is the better compression but quality may degrade. I'd suggest you use these 3/3 values or max. 4/4.
I've put settings that should provide real nice quality with less encoding time. Also I tried to make the output uncropped.mkv to be in size almost as the original. You can experiment with different settings in shorter clips and see the difference.
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