[High Speed Dubb]

I haven’t used AVISynth, so I don’t know the best filters and settings for noise reduction. But based on the way noise filtering works — Yes, you should use much more aggressive noise reduction with cartoons. That’s for two reasons: 1) Animation tends to have very well defined boundaries, so you get fewer artifacts, and 2) Animation tends to have plainly shaded regions, so noise is more visible.

So just increase the amount of noise reduction when processing animation and the resulting image should look much nicer.

(I wonder if the board will mess up my signature smiley?)